It would not be a good weapon for offence or defence, the recoil is far to much for quick follow up shots, plus when I shot one it jammed alot...
A good ol .45ACP is just as good without all the recoil and muzzle flash, or they do have the new .50GI. Dont know much about it but they have some 1911's that can fire it.
although I must say... it would be a bad ass gun to pull out on someone... be like all AHnold style and stuff.